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Islamically Permissible Influenza Vaccines Available in the US for 2020-2021 Season

Prepared by Mawlana Dr. Mateen A. Khan, MD and Dr. Ramzan Judge, PharmD


Permissible influenza vaccines in the US for 2020-2021 season

  • FluadTM Trivalent

  • FluadTM Quadrivalent

  • Fluzone High-DoseTM Quadrivalent

  • AfluriaTM

  • FluarixTM

  • FluLavalTM

  • FluzoneTM Quadrivalent

Impermissible influenza vaccines in the US for 2020-2021 season

  • FlublokTM

  • FluMistTM

  • FlucelvaxTM


Background on Influenza

Influenza (commonly known as the flu) is a seasonal viral illness carrying significant health, economic, and social burden. For the past nine years, the Centers for Disease Control and Prevention (CDC) estimates that every year 9.3-49 million symptomatic illnesses, 4.3-23 million medical visits, 140,000-960,000 hospitalizations, and 12,000-79,000 deaths are attributed to seasonal influenza. For the 2017-2018 season, which was considered high severity, a study estimated influenza vaccination prevented:

  • 7.1 million illnesses

  • 3.7 million medical visits

  • 109,000 hospitalizations (10% of expected overall and 41% among young children)

  • 8,000 deaths[i]

In addition to providing immunity to healthy individuals, the vaccine benefits the sick by decreasing the amount of exposure from other individuals (herd immunity). Hence, the CDC, along with most American medical organizations, recommends that every person above six months old receive a seasonal influenza vaccine yearly.[ii]

Improving vaccination rates among Muslims has been a struggle. Muslim majority countries find their populations hesitant. [iii] Similar issues are faced among Muslim minority populations in the West over a concern for the presence of impermissible ingredients in the vaccine.[iv]

The United States currently offers nine different commercially prepared vaccines. We reviewed package inserts and public records for the vaccines to evaluate methods of production and the presence of impermissible products. When necessary, we corresponded with the manufacturers. The results are compiled in Table 1. The vaccines vary in their methods of production and ingredients, which may pose religious challenges for Muslims.

Issue #1 – Methods of Production

Influenza vaccines are prepared through three different processes. Most strains are prepared through an egg-based manufacturing process. This involves injecting vaccine viruses into fertilized chicken eggs. Essentially, the egg is commandeered as a factory by the viruses as they use the egg’s resources to replicate themselves. The viruses are extracted and purified.[v] Islamically, this process per se is not an issue as eggs are considered permissible.

Flucelvax™, a product by Seqirus, is made by incubating influenza viruses in a particular animal cell line, Madin-Darby Canine Kidney (MDCK).[vi] The MDCK cell line was initially isolated in 1958 from an adult Cocker Spaniel dog.[vii] Dogs, like all predators, are ḥarām as Sayyidunā Ibn `Abbās (May Allah be pleased with him) narrated that Allah’s Messenger ﷺ prohibited every predator possessing canine teeth.[viii] Further, when cells like MDCK are removed from an animal, they are considered maytah (carrion) in Islamic terminology. The Prophet ﷺ informed us, “Whatever is cut from an animal while it is alive is carrion.”[ix] Surah al-An`ām states a ruling of najis and ḥarām for carrion.

“Say, “I do not find, in what has been revealed to me, anything prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure.”[x]

Hence, the initially harvested canine cells were najis and ḥarām. Since 1958, the cell line has undergone countless replication cycles in artificial environments, and the parent cells have long died off. Still, being the progeny cells, they will be impure and impermissible.

The MDCK cells used in Flucelvax™ are grown in a medium in which no human or animal-derived materials are used.[xi] After an incubation period, the cells are processed through lysis, and the virus proteins undergo extraction and purification. Despite this, residual amounts of the cells capable of inducing allergic reaction in susceptible patients remain, per the package insert. For these reasons, Flucelvax™ vaccine made from this method is impermissible.

FlublokTM manufactured by Sanofi, is produced by genetically engineering proteins expressed by influenza into an alternate virus, baculovirus (Autographa californica). It is then used to infect an insect cell line (ExpresSF+) derived from the fall armyworm (Spodoptera frugiperda), which produces the desired influenza proteins. This vaccine is especially valuable to those who have severe allergies to eggs. [xii] Insects, like the armyworm, fall into the category of al-khabā’ith explicitly mentioned in the Qur’an as ḥarām in Surah al-A`rāf.

[He ﷺ] makes unlawful for them impure things (al-khabā’ith).[xiii]

Similar to animal cell lines discussed previously, the progeny ExpresSF+ cells are impure and impermissible. Hence, FlublokTM vaccine made from this method is also impermissible.

Issue #2 – Porcine Gelatin as a Stabilizer

Two of the vaccines available in the United States, FluMistTM and Flucelvax™, contain porcine gelatin. The gelatin is added as a stabilizer for the viral vaccine protein. Gelatin is hydrolyzed collagen, which is extracted from collagen-containing tissue like skin and bones. At the outset, the Qur’an declares that all porcine parts are najis and ḥarām.

Say, “I do not find, in what has been revealed to me, anything (out of the cattle under discussion) prohibited for anyone who eats it, unless it be carrion or blood that pours forth, or flesh of swine – because it is impure – or there be an animal slaughtered sinfully by invoking on it the name of someone other than Allah. (Surah al-An`ām:145)[xiv]

He has but prohibited for you the carrion, the blood, the flesh of swine and what has been invoked upon with a name other than that of Allah. (Surah al-Naḥl:115)[xv]

In earlier times, gelatin was prepared in homes through a process of cooking, causing the collagen to hydrolyze and break into peptides of varying lengths. Although the process today is commercialized and done through a series of chemical reactions, extraction, and purification, the result is not much different from home preparations. These peptides do not constitute a significant change from the original porcine collagen. Instead, gelatin is just fragmented hydrolyzed collagen. The resulting gelatin is impermissible.[xvi] Hence, FluMistTM and Flucelvax™ are impermissible particularly when other permissible alternatives exist.

Exceptional Cases

If someone is unable to take or obtain one of the permissible influenza vaccines, and they are relatively healthy, they should not take an impermissible vaccine.[xvii] However, if a strong need exists, then they may take those vaccines that are normally impermissible. An example of a strong medical need is when there is a high likelihood (ghalabah al-ẓann) of significant morbidity or mortality in contracting influenza such as in the very old or patients with pre-existing significant comorbidities. Ideally, the Sharī`ah prefers a competent Muslim physician to determine this need based upon the evidences at hand. The physician should be pious and have a basic understanding of the relevant Sharī`ah rulings.[xviii] Vaccinations mandated by the government, work places, or schools may also constitute a strong need.[xix] In any of these situations, one may take (in order of preference) FlublokTM, FluMistTM, and FlucelvaxTM.


Of the ten commercially available influenza vaccines available in the US for the 2020-2021 season, seven are Islamically permissible: FluadTM Trivalent, FluadTM Quadrivalent, Fluzone High-DoseTM, AfluriaTM, FluarixTM, FluLavalTM, and FluzoneTM Quadrivalent. The Muslim public is advised to avoid FlublokTM, FluMistTM, and FlucelvaxTM.

In exceptional cases, as outlined above, one may take FlublokTM, FluMistTM, and FlucelvaxTM in that order.

Of note, vaccine formulations are subject to change year to year. The research presented here is accurate for the 2020-2021 season.

Table 1: 2020-2021 Influenza Vaccines

[i] Rolfes, M.A. (2019). Effects of Influenza Vaccination in the United States During the 2017–2018 Influenza Season. Clinical Infectious Diseases, ciz075,

[iii] Ahmed, A. (2018) Outbreak of vaccine-preventable diseases in Muslim majority countries. Journal of Infection and Public Health, 11 (2), 153-155.

[viii] عَنِ ابْنِ عَبَّاسٍ، قَالَ نَهَى رَسُولُ اللَّهِ صلى الله عليه وسلم عَنْ كُلِّ ذِي نَابٍ مِنَ السِّبَاعِ (مسلم 1934)

[ix] مَا قُطِعَ مِنَ الْبَهِيمَةِ وَهِيَ حَيَّةٌ فَهِيَ مَيْتَةٌ (أبو داوود 2858، الترمذي 1480، ابن ماجه 3216)

وَعَلَى هَذَا يَخْرُجُ مَا إذَا قَطَعَ مِنْ أَلْيَةِ الشَّاةِ قِطْعَةً أَوْ مِنْ فَخِذِهَا أَنَّهُ لَا يَحِلُّ الْمُبَانُ وَإِنْ ذُبِحَتْ الشَّاةُ بَعْدَ ذَلِكَ؛ لِأَنَّ حُكْمَ الذَّكَاةِ لَمْ يَثْبُتْ فِي الْجُزْءِ الْمُبَانِ وَقْتَ الْإِبَانَةِ لِانْعِدَامِ ذَكَاةِ الشَّاةِ لِكَوْنِهَا حَيَّةً وَقْتَ الْإِبَانَةِ، وَحَالَ فَوَاتِ الْحَيَاةِ كَانَ الْجُزْءُ مُنْفَصِلًا وَحُكْمُ الذَّكَاةِ لَا يَظْهَرُ فِي الْجُزْءِ الْمُنْفَصِلِ وَرُوِيَ أَنَّ أَهْلَ الْجَاهِلِيَّةِ كَانُوا يَقْطَعُونَ قِطْعَةً مِنْ أَلْيَةِ الشَّاةِ وَمِنْ سَنَامِ الْبَعِيرِ فَيَأْكُلُونَهَا فَلَمَّا بُعِثَ النَّبِيُّ الْمُكَرَّمُ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – نَهَاهُمْ عَنْ ذَلِكَ فَقَالَ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «مَا أُبِينَ مِنْ الْحَيِّ فَهُوَ مَيِّتٌ» وَالْجُزْءُ الْمَقْطُوعُ مُبَانٌ مِنْ حَيٍّ وَبَائِنٌ مِنْهُ فَيَكُونُ مَيِّتًا وَكَذَلِكَ إذَا قُطِعَ ذَلِكَ مِنْ صَيْدٍ لَمْ يُؤْكَلْ الْمَقْطُوعُ، وَإِنْ مَاتَ الصَّيْدُ بَعْدَ ذَلِكَ لِمَا قُلْنَا. (بدائع الصنائع في ترتيب الشرائع)

[x] قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xi] European Medicines Agency Assessment Report on Flucelvax Tetra. 18 Oct. 2018. Pg. 14.

[xii] Barr, I. G. (2018). Cell culture-derived influenza vaccines in the severe 2017-2018 epidemic season: a step towards improved influenza vaccine effectiveness. NPJ vaccines, 3, 44. doi:10.1038/s41541-018-0079-z

See also for discussion on egg allergies and influenza vaccines.

[xiii] وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ

(وَأَمَّا) الَّذِي يَعِيشُ فِي الْبَرِّ فَأَنْوَاعٌ ثَلَاثَةٌ: مَا لَيْسَ لَهُ دَمٌ أَصْلًا، وَمَا لَيْسَ لَهُ دَمٌ سَائِلٌ، وَمَا لَهُ دَمٌ سَائِلٌ مِثْلُ الْجَرَادِ وَالزُّنْبُورِ وَالذُّبَابِ

وَالْعَنْكَبُوتِ وَالْعَضَّابَةِ وَالْخُنْفُسَاءِ وَالْبُغَاثَةِ وَالْعَقْرَبِ.

وَنَحْوِهَا لَا يَحِلُّ أَكْلُهُ إلَّا الْجَرَادَ خَاصَّةً؛ لِأَنَّهَا مِنْ الْخَبَائِثِ لِاسْتِبْعَادِ الطِّبَاعِ السَّلِيمَةِ إيَّاهَا وَقَدْ قَالَ اللَّهُ تَبَارَكَ وَتَعَالَى {وَيُحَرِّمُ عَلَيْهِمُ الْخَبَائِثَ} [الأعراف: 157] إلَّا أَنَّ الْجَرَادَ خُصَّ مِنْ هَذِهِ الْجُمْلَةِ بِقَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «أُحِلَّتْ لَنَا مَيْتَتَانِ» فَبَقِيَ عَلَى ظَاهِرِ الْعُمُومِ. وَكَذَلِكَ مَا لَيْسَ لَهُ دَمٌ سَائِلٌ مِثْلُ الْحَيَّةِ وَالْوَزَغِ وَسَامِّ أَبْرَصَ وَجَمِيعِ الْحَشَرَاتِ وَهَوَامِّ الْأَرْضِ مِنْ الْفَأْرِ وَالْقُرَادِ وَالْقَنَافِذِ وَالضَّبِّ وَالْيَرْبُوعِ وَابْنِ عِرْسٍ وَنَحْوِهَا، وَلَا خِلَافَ فِي حُرْمَةِ هَذِهِ الْأَشْيَاءِ إلَّا فِي الضَّبِّ (بدائع الصنائع في ترتيب الشرائع)

[xiv] قُل لَّا أَجِدُ فِي مَا أُوحِيَ إِلَيَّ مُحَرَّمًا عَلَىٰ طَاعِمٍ يَطْعَمُهُ إِلَّا أَن يَكُونَ مَيْتَةً أَوْ دَمًا مَّسْفُوحًا أَوْ لَحْمَ خِنزِيرٍ فَإِنَّهُ رِجْسٌ أَوْ فِسْقًا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xv] إِنَّمَا حَرَّمَ عَلَيْكُمُ الْمَيْتَةَ وَالدَّمَ وَلَحْمَ الْخِنزِيرِ وَمَا أُهِلَّ لِغَيْرِ اللَّـهِ بِهِ

[xvi] Respectfully, the minority opinion considering gelatin to have undergone a significant transformation (tabdīl al-mahiyah) rendering its ruling changed seems doubtful for the reasons outlined. This is an extensive discussion. However, with the availability of clearly ḥalāl alternatives, the opinion given in this article is more cautious.

[xvii] The authors are currently unaware of any clinical scenario in which an Islamically permissible vaccine is contraindicated. The CDC recommends egg cultured vaccines even in patients with prior anaphylactic reactions to eggs. (See: This statement is included as a hypothetical clinical scenario.

[xviii] وَجَوَّزَهُ فِي النِّهَايَةِ بِمُحَرَّمٍ إذَا أَخْبَرَهُ طَبِيبٌ مُسْلِمٌ أَنَّ فِيهِ شِفَاءً وَلَمْ يَجِدْ مُبَاحًا يَقُومُ مَقَامَهُ. قُلْت: وَفِي الْبَزَّازِيَّةِ وَمَعْنَى قَوْلِهِ – عَلَيْهِ الصَّلَاةُ وَالسَّلَامُ – «إنَّ اللَّهَ لَمْ يَجْعَلْ شِفَاءَكُمْ فِيمَا حُرِّمَ عَلَيْكُمْ» نَفْيُ الْحُرْمَةِ عِنْدَ الْعِلْمِ بِالشِّفَاءِ دَلَّ عَلَيْهِ جَوَازُ شُرْبِهِ لِإِزَالَةِ الْعَطَشِ (رد المحتار على الدر المختار)

[xix] Imdād al-Fatāwa Jadīd ma`a Hāshiyah Shabbīr Aḥmad al-Qāsimī, 9:262



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